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    A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor
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    PNAS first published October 14, 2019. https://doi.org/10.1073/pnas.1908662116
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    Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome
    Theodora Panagaki, Elisa B. Randi, Fiona Augsburger, and Csaba Szabo
    PNAS September 17, 2019 116 (38) 18769-18771; first published September 3, 2019. https://doi.org/10.1073/pnas.1911895116
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    Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice
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    Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain
    Guillaume Ferré, Maxime Louet, Oliver Saurel, Bartholomé Delort, Georges Czaplicki, Céline M’Kadmi, Marjorie Damian, Pedro Renault, Sonia Cantel, Laurent Gavara, Pascal Demange, Jacky Marie, Jean-Alain Fehrentz, Nicolas Floquet, Alain Milon, and Jean-Louis Banères
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    SR9009 has REV-ERB–independent effects on cell proliferation and metabolism
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    Variable G protein determinants of GPCR coupling selectivity
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    PNAS June 11, 2019 116 (24) 12054-12059; first published May 29, 2019. https://doi.org/10.1073/pnas.1905993116
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    Interrogating dense ligand chemical space with a forward-synthetic library
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    PNAS June 4, 2019 116 (23) 11496-11501; first published May 21, 2019. https://doi.org/10.1073/pnas.1818718116
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    sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
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    Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain
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    PNAS May 21, 2019 116 (21) 10557-10562; first published May 8, 2019. https://doi.org/10.1073/pnas.1820466116
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    Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement
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